Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.64 |
| ▸ | MLYCD | O95822 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | ACR | P10323 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28459342 | 0.83 | KIF11 (0.66) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL4316832 | 0.82 | KIF11 (0.89) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL4598278 | 0.82 | KIF11 (0.60) | KIF11MEN1KMT2A | |
| SCHEMBL28909073 | 0.81 | KIF11 (0.86) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL29177337 | 0.79 | KIF11 (0.66) | KIF11SMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL18479637 | 0.79 | ELANE (0.59) | MLYCDSMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL22336441 | 0.79 | NR1H2 (0.47) | KIF11MLYCDSMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL29177191 | 0.77 | KIF11 (0.58) | KIF11SMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL6284986 | 0.77 | KMT2A (0.64) | KIF11SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL15840341 | 0.76 | ELANE (0.50) | MLYCDSMN1; SMN2NR1H2NR1H3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072542-A | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-110730780-A | 2, 3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators | 阿斯利康(瑞典)有限公司 | 2020-01-24 | — | — | CN | disclosed |