Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22684781 | 0.88 | MEN1 (0.44) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21176846 | 0.85 | KMT2A (0.46) | CES2CES1KMT2AMEN1ALDH1A1 | |
| SCHEMBL22609299 | 0.85 | MEN1 (0.46) | CES2CES1KMT2AMEN1ALDH1A1 | |
| SCHEMBL603711 | 0.84 | HTT (0.45) | KMT2AMEN1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL28366289 | 0.83 | MEN1 (0.40) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3613187 | 0.83 | ALDH1A1 (0.42) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1119176 | 0.82 | CES2 (0.59) | CES2CES1KMT2AMEN1ALDH1A1 | |
| SCHEMBL27818031 | 0.81 | MEN1 (0.46) | CES2CES1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10562025 | 0.81 | CES2 (0.43) | CES2CES1KMT2AMEN1ALDH1A1 | |
| SCHEMBL8749059 | 0.80 | CES1 (0.57) | CES2CES1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110734441-B | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-09-04 | — | — | CN | claimed |
| CN-110734441-A | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-01-31 | — | — | CN | claimed |
| CN-110734441-B | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-09-04 | — | — | CN | disclosed |
| CN-110734441-A | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-01-31 | — | — | CN | disclosed |