Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | PAM | P19021 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PPID | Q08752 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28547028 | 0.85 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28366287 | 0.83 | CES2 (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27818031 | 0.77 | MEN1 (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL20109333 | 0.75 | ALDH1A1 (0.49) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL884443 | 0.74 | ALDH1A1 (0.59) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27897071 | 0.74 | L3MBTL1 (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3613187 | 0.73 | ALDH1A1 (0.42) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL22684781 | 0.71 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1119176 | 0.71 | CES2 (0.59) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL12924796 | 0.70 | MEN1 (0.49) | MEN1KMT2AALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110734441-B | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-09-04 | — | — | CN | claimed |
| CN-110734441-A | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-01-31 | — | — | CN | claimed |
| CN-110734441-B | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-09-04 | — | — | CN | disclosed |
| CN-110734441-A | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-01-31 | — | — | CN | disclosed |