Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28365570 | 0.83 | TDP1 (0.38) | MAPTVCPPLA2G10MEN1KMT2A | |
| SCHEMBL28365300 | 0.81 | VCP (0.38) | MAPTVCPPLA2G10KMT2AMGLL | |
| SCHEMBL28202823 | 0.79 | ALDH1A1 (0.50) | VCPPLA2G10MEN1KMT2ANOTUM | |
| SCHEMBL28365057 | 0.78 | CYP19A1 (0.46) | MAPTVCPMDM2PLA2G10MEN1 | |
| SCHEMBL28369113 | 0.75 | CYP19A1 (0.52) | VCPPLA2G10NOTUMTSHRALDH1A1 | |
| SCHEMBL28369134 | 0.73 | BIRC5 (0.44) | MAPTVCPMDM2PLA2G10NOTUM | |
| SCHEMBL28365347 | 0.73 | NOTUM (0.40) | MAPTVCPPLA2G10KMT2ANOTUM | |
| SCHEMBL28365207 | 0.73 | KDM4E (0.47) | MAPTVCPMDM2PLA2G10MEN1 | |
| SCHEMBL28338755 | 0.72 | PLA2G10 (0.38) | MAPTVCPPLA2G10KMT2ANOTUM | |
| SCHEMBL28365059 | 0.71 | MDM2 (0.40) | MAPTVCPMDM2PLA2G10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107619385-B | Method for synthesizing 2-trifluoromethyl indole by palladium-catalyzed aryl enamine intramolecular amine | 温州大学 | 2020-02-21 | — | — | CN | disclosed |