Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | OGG1 | O15527 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750114 | 0.80 | HDAC8 (0.45) | ALDH1A1LMNAMAPTL3MBTL1TDP1 | |
| SCHEMBL8631005 | 0.79 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPTL3MBTL1TDP1 | |
| SCHEMBL7217724 | 0.79 | L3MBTL1 (0.48) | ALDH1A1LMNAMAPTL3MBTL1GAA | |
| SCHEMBL25233005 | 0.78 | HPGD (0.46) | ALDH1A1KDM4EMAPTL3MBTL1GAA | |
| SCHEMBL1674356 | 0.77 | — | — | |
| SCHEMBL26469193 | 0.77 | GAA (0.56) | ALDH1A1LMNAKDM4EMAPTL3MBTL1 | |
| SCHEMBL27682287 | 0.76 | CES2 (0.39) | ALDH1A1LMNATDP1RAB9ANPC1 | |
| SCHEMBL29450062 | 0.76 | DAO (0.59) | ALDH1A1LMNAOGG1KDM4EMAPT | |
| SCHEMBL655351 | 0.76 | DAO (0.59) | ALDH1A1LMNAMAPTL3MBTL1TDP1 | |
| SCHEMBL20521778 | 0.74 | SMYD3 (0.46) | ALDH1A1MAPTL3MBTL1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065383-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010039913-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |