Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 3/20 | 0.38 |
| ▸ | MPO | P05164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18073156 | 0.75 | ALDH1A1 (0.48) | ATMMPOKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL17981694 | 0.72 | ATM (0.56) | ATMMPOKDM4EMAPTKMT2A | |
| SCHEMBL17324739 | 0.72 | KDM5A (0.42) | ATMKDM4EGAAMAPTRAB9A | |
| SCHEMBL15701333 | 0.71 | HDAC3 (0.56) | HPSEGAARAB9ASMN1; SMN2KMT2A | |
| SCHEMBL17981714 | 0.68 | MPO (0.46) | ATMMPOKDM4ERECQL | |
| SCHEMBL29004878 | 0.67 | ELANE (0.41) | KDM4EGLAGAAMAPTRAB9A | |
| SCHEMBL28546173 | 0.67 | POLB (0.44) | KDM4EMAPTSMN1; SMN2LMNAF2 | |
| SCHEMBL25966964 | 0.66 | ALDH1A1 (0.48) | ATMMPOKDM4ESMN1; SMN2 | |
| SCHEMBL17324830 | 0.66 | ROCK1 (0.48) | ATMTOP2AMPOKDM4E | |
| SCHEMBL27735636 | 0.66 | L3MBTL1 (0.46) | KDM4ESMN1; SMN2LMNAELANEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111171047-A | Fused dihydro-4H-pyrazolo [5,1-C ] [1,4] oxazinyl compounds for the treatment of CNS disorders | 赛诺维信制药公司 | 2020-05-19 | — | — | CN | disclosed |
| CN-107567454-B | Fused dihydro-4H-pyrazolo [5,1-C ] [1,4] oxazinyl compounds and analogs thereof for the treatment of CNS disorders | 赛诺维信制药公司 | 2020-02-18 | — | — | CN | disclosed |