Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740583 | 1.00 | APP (0.43) | APPERN1MAPK14AAK1TRPA1 | |
| SCHEMBL29740596 | 0.79 | APP (0.43) | APPMAPK14TRPA1LMNAKMT2A | |
| SCHEMBL28372343 | 0.79 | APP (0.43) | APPMAPK14TRPA1LMNAKMT2A | |
| SCHEMBL17041591 | 0.78 | TRPA1 (0.43) | AAK1TRPA1SERPINE1KMT2A | |
| SCHEMBL25972307 | 0.72 | APP (0.45) | APPAAK1RIPK1CES2CES1 | |
| SCHEMBL22624144 | 0.72 | ERN1 (0.37) | ERN1RIPK1CES2CES1SLC6A3 | |
| SCHEMBL19439613 | 0.70 | CA1 (0.50) | ERN1LMNA | |
| SCHEMBL28968845 | 0.70 | ACHE (0.39) | APPSERPINE1LMNAKMT2A | |
| SCHEMBL24940764 | 0.70 | APP (0.49) | APPAAK1TRPA1LMNAKMT2A | |
| SCHEMBL5074832 | 0.69 | ALDH1A1 (0.34) | APPCES2CES1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110950890-B | Substituted imidazo [4,5-c ] quinoline macrocycles as multi-target kinase inhibitors | 北京赛林泰医药技术有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-110950890-A | Substituted imidazo [4,5-c ] quinoline macrocycles as multi-target kinase inhibitors | 北京赛林泰医药技术有限公司 | 2020-04-03 | — | — | CN | disclosed |