Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28372343 | 1.00 | APP (0.43) | APPPTGS1PTGS2GABRA1GABRG2 | |
| SCHEMBL29740583 | 0.79 | APP (0.43) | APPLMNAKMT2AMAPK14TRPA1 | |
| SCHEMBL28374072 | 0.79 | APP (0.43) | APPLMNAKMT2AMAPK14TRPA1 | |
| SCHEMBL27520331 | 0.79 | PTGS1 (0.42) | PTGS1PTGS2PSEN1PSEN2APH1B | |
| SCHEMBL23047197 | 0.78 | TRPA1 (0.43) | LMNAKMT2AKDM4DTRPA1ALDH1A1 | |
| SCHEMBL29617270 | 0.78 | TRPA1 (0.43) | LMNAKMT2AKDM4DTRPA1ALDH1A1 | |
| SCHEMBL23047198 | 0.78 | TRPA1 (0.43) | LMNAKMT2AKDM4DTRPA1ALDH1A1 | |
| SCHEMBL7746373 | 0.78 | GABRA1 (0.47) | APPPTGS1PTGS2GABRA1GABRG2 | |
| SCHEMBL28968845 | 0.76 | ACHE (0.39) | APPLMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL27463423 | 0.74 | APP (0.50) | APPPTGS1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110950890-B | Substituted imidazo [4,5-c ] quinoline macrocycles as multi-target kinase inhibitors | 北京赛林泰医药技术有限公司 | 2022-07-01 | — | — | CN | disclosed |