Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2838115 | 0.84 | CASR (0.55) | CASRGRM5GCKLTA4HMAPK14 | |
| SCHEMBL2840670 | 0.84 | HTR2C (0.40) | HTR2CSLC6A4C5AR1PSEN1PSEN2 | |
| SCHEMBL4156885 | 0.78 | CASR (0.44) | HTR2CSLC6A4CASRCTSSHPGD | |
| SCHEMBL2843300 | 0.77 | CASR (0.52) | HTR2CSLC6A4CASRC5AR1PSEN1 | |
| SCHEMBL27730648 | 0.71 | CASR (0.46) | HTR2CSLC6A4CASRHPGDCNR1 | |
| SCHEMBL4143491 | 0.71 | CASR (0.67) | CASR | |
| SCHEMBL2839722 | 0.67 | TSHR (0.46) | CASRGRM5LTA4HMAPK14 | |
| SCHEMBL2839694 | 0.64 | CYP1A2 (0.43) | CASRGRM5LTA4HMAPK14 | |
| SCHEMBL2838847 | 0.64 | CASR (0.55) | CASRGCKLTA4HMAPK14 | |
| SCHEMBL13851700 | 0.64 | BRD4 (0.44) | CASRGRM5PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039913-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |