Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143491 | 0.85 | CASR (0.67) | CASRTSHRALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2837495 | 0.84 | HTR2C (0.41) | CASRGRM5LTA4HMAPK14GCK | |
| SCHEMBL2839722 | 0.81 | TSHR (0.46) | CASRTSHRALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2839694 | 0.78 | CYP1A2 (0.43) | CASRTSHRALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2838847 | 0.77 | CASR (0.55) | CASRTSHRALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL4151611 | 0.76 | CASR (0.70) | CASRTSHRALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL4143702 | 0.76 | CASR (0.70) | CASRTSHRALDH1A1LMNAMEN1 | |
| SCHEMBL2837296 | 0.76 | CASR (0.49) | CASRTSHRALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL4143102 | 0.75 | CASR (0.51) | CASRTSHRALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL14535990 | 0.75 | CASR (0.53) | CASRTSHRALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039913-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |