Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | KMO | O15229 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MGLL | Q99685 | 2/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.48 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731883 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAOAKMOMEN1ESR1 | |
| SCHEMBL31734209 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAOAKMOMEN1ESR1 | |
| SCHEMBL29354148 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAOAKMOMEN1ESR1 | |
| Biphenyl SCHEMBL11687528 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAOAKMOMEN1ESR1 | |
| SCHEMBL51426 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAOAKMOMEN1ESR1 | |
| SCHEMBL2401076 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAOAKMOMEN1ESR1 | |
| SCHEMBL6918022 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAOAKMOMEN1ESR1 | |
| SCHEMBL14481975 | 0.93 | ALDH1A1 (0.64) | ALDH1A1MAOAKMOMEN1ESR1 | |
| SCHEMBL31254135 | 0.93 | ALDH1A1 (0.64) | ALDH1A1MAOAKMOMEN1ESR1 | |
| SCHEMBL22113250 | 0.93 | ALDH1A1 (0.64) | ALDH1A1MAOAKMOMEN1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12297311-B2 | Biaryl hydroxythiophene group IV transition metal polymerization with chain transfer capability | DOW GLOBAL TECHNOLOGIES LLC (US) | 2025-05-13 | — | — | US | disclosed |
| EP-3642250-B1 | BIARYL PHENOXY GROUP IV TRANSITION METAL CATALYSTS FOR OLEFIN POLYMERIZATION | DOW GLOBAL TECHNOLOGIES LLC (US) | 2024-12-18 | — | — | EP | disclosed |
| US-12122862-B2 | Biaryl hydroxythiophene group IV transition metal polymerization catalysts with chain transfer capability | DOW GLOBAL TECHNOLOGIES LLC (US) | 2024-10-22 | — | — | US | disclosed |
| US-20220169756-A1 | BIARYL HYDROXYTHIOPHENE GROUP IV TRANSITION METAL POLYMERIZATION WITH CHAIN TRANSFER CAPABILITY | DOW GLOBAL TECHNOLOGIES LLC (US) | 2022-06-02 | — | — | US | disclosed |
| CN-110809586-A | Biarylphenoxy group IV transition metal catalysts for olefin polymerization | 陶氏环球技术有限责任公司 | 2020-02-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12122862-B2 | Biaryl hydroxythiophene group IV transition metal polymerization catalysts with chain transfer capability | TRMT1, GFPT1, BCAT1 | ALDH1A1 421/4885MAOA 914/4885KMO 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.