Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 4/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28378617 | 0.88 | PIM1 (0.41) | MAPK10PIM1PIM3TSHRATM | |
| SCHEMBL28378703 | 0.83 | TSHR (0.59) | MAPK10TSHRATMPOLBMAPK8 | |
| SCHEMBL28378686 | 0.79 | CHEK1 (0.55) | IRAK4 | |
| SCHEMBL28383371 | 0.77 | PIM1 (0.55) | MAPK10PIM1PIM3TSHRATM | |
| SCHEMBL29033319 | 0.76 | HPGD (0.42) | MAPK10TSHRATMPOLBNPSR1 | |
| SCHEMBL30501501 | 0.68 | PIM1 (0.51) | PIM1PIM3TSHRNPSR1KDM4E | |
| SCHEMBL20598735 | 0.68 | NTRK1 (0.57) | PIM1PIM3TSHRNPSR1ALDH1A1 | |
| SCHEMBL20598482 | 0.68 | PIM1 (0.51) | PIM1PIM3TSHRNPSR1KDM4E | |
| SCHEMBL30501448 | 0.68 | NTRK1 (0.57) | PIM1PIM3TSHRNPSR1ALDH1A1 | |
| SCHEMBL20598489 | 0.67 | IRAK4 (0.50) | PIM1PIM3TSHRPOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-A | Kinase inhibitors and methods of making and using | 里格尔药品股份有限公司 | 2020-04-17 | — | — | CN | disclosed |