Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28378703 | 0.83 | TSHR (0.59) | HPGDSMN1; SMN2GAATSHRATM | |
| SCHEMBL28378686 | 0.82 | CHEK1 (0.55) | IRAK4 | |
| SCHEMBL29033220 | 0.82 | HPGD (0.52) | HPGDSMN1; SMN2GAALMNAMAPT | |
| SCHEMBL28384221 | 0.81 | HPGD (0.51) | HPGDSMN1; SMN2GAALMNAMAPT | |
| SCHEMBL28887694 | 0.78 | HPGD (0.50) | HPGDSMN1; SMN2GAALMNAMAPT | |
| SCHEMBL28378617 | 0.76 | PIM1 (0.41) | KDM4ETSHRATMPOLBNPSR1 | |
| SCHEMBL28382394 | 0.76 | MAPK10 (0.46) | HPGDSMN1; SMN2KDM4ETSHRATM | |
| SCHEMBL20598344 | 0.72 | CSF1R (0.55) | HPGDSMN1; SMN2GAALMNAMAPT | |
| SCHEMBL20598310 | 0.72 | CSF1R (0.55) | HPGDSMN1; SMN2GAALMNAMAPT | |
| SCHEMBL20598458 | 0.71 | IRAK4 (0.50) | HPGDSMN1; SMN2GAALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | claimed |
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |