Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 18/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 16/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29033319 | 0.83 | HPGD (0.42) | TSHRPOLBATMCSF1RMAPK10 | |
| SCHEMBL28382394 | 0.83 | MAPK10 (0.46) | TSHRPOLBATMMAPK10MAPK8 | |
| SCHEMBL28378617 | 0.81 | PIM1 (0.41) | TSHRPOLBATMMAPK10MAPK8 | |
| SCHEMBL28379784 | 0.77 | MAPK10 (0.74) | TSHRPOLBATMCSF1RMAPK10 | |
| SCHEMBL28378686 | 0.73 | CHEK1 (0.55) | — | |
| SCHEMBL13147762 | 0.71 | CSF1R (1.00) | TSHRPOLBATMCSF1RMAPK10 | |
| SCHEMBL13167004 | 0.70 | ALDH1A1 (1.00) | TSHRPOLBATMCSF1RMAPK10 | |
| SCHEMBL20598829 | 0.65 | NPC1 (0.72) | TSHRCSF1RMAPK10ALDH1A1GAA | |
| SCHEMBL20598140 | 0.65 | ALDH1A1 (0.67) | TSHRCSF1RMAPK10ALDH1A1GAA | |
| SCHEMBL28887709 | 0.64 | CSF1R (0.57) | TSHRPOLBATMCSF1RMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-111032642-A | Kinase inhibitors and methods of making and using | 里格尔药品股份有限公司 | 2020-04-17 | — | — | CN | disclosed |