Sugi Predict

Sugi Predict / Compounds / SCHEMBL28381

SCHEMBL28381

SCHEMBL28381

CON(C)C(=O)c1[nH]c(C)c(-c2nc3ccc(C(=O)c4ccccc4)cc3[nH]2)c1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGDS O60760 2/20 1.00
▸ ALDH1A1 P00352 3/20 0.52
▸ HPGD P15428 2/20 0.52
▸ POLB P06746 2/20 0.52
▸ RAB9A P51151 1/20 0.52
▸ SMN1; SMN2 Q16637 1/20 0.52
▸ ABL1 P00519 3/20 0.51
▸ LMNA P02545 2/20 0.51
▸ HTT P42858 2/20 0.51
▸ ABCC4 O15439 1/20 0.51
▸ USP2 O75604 1/20 0.51
▸ CYP1A2 P05177 1/20 0.51
▸ CYP2C9 P11712 1/20 0.51
▸ KDR P35968 1/20 0.51
▸ HIF1A Q16665 1/20 0.51
▸ ESR1 P03372 1/20 0.49
▸ MEN1 O00255 1/20 0.48
▸ KMT2A Q03164 1/20 0.48
▸ CHEK2 O96017 2/20 0.47
▸ METAP1 P53582 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28380 0.92 HPGDS (0.86) HPGDSALDH1A1HPGDPOLBRAB9A
SCHEMBL1799022 0.90 HPGDS (0.82) HPGDSALDH1A1HPGDPOLBRAB9A
SCHEMBL1800667 0.86 HPGDS (0.74) HPGDSALDH1A1HPGDPOLBRAB9A
SCHEMBL1800385 0.85 HPGDS (0.74) HPGDSALDH1A1HPGDPOLBRAB9A
SCHEMBL1799868 0.84 HPGDS (0.72) HPGDSALDH1A1HPGDPOLBRAB9A
SCHEMBL1799756 0.83 HPGDS (0.72) HPGDSALDH1A1HPGDPOLBRAB9A
SCHEMBL1799020 0.82 HPGDS (0.69) HPGDSALDH1A1HPGDPOLBRAB9A
SCHEMBL1802044 0.82 HPGDS (0.69) HPGDSALDH1A1HPGDPOLBRAB9A
SCHEMBL1800622 0.81 HPGDS (0.68) HPGDSALDH1A1HPGDPOLBRAB9A
SCHEMBL1803458 0.80 HPGDS (0.67) HPGDSALDH1A1HPGDPOLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3782648-B1 PROSTAGLANDIN D2 PRODUCTION INHIBITORS AS PREVENTATIVE AND THERAPEUTIC AGENTS FOR SARCOPENIA NATIONAL UNIV CORPORATION TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY (JP) 2024-09-18 — — EP claimed
US-20210161908-A1 PREVENTATIVE AND THERAPEUTIC AGENTS FOR SARCOPENIA NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY (JP) 2021-06-03 — — US claimed
EP-3782648-A1 PREVENTATIVE AND THERAPEUTIC AGENTS FOR SARCOPENIA National University Corporation Tokyo University of Agriculture and Technology (JP) 2021-02-24 — — EP claimed
CN-111989119-A Prophylactic and therapeutic agent for sarcopenia 国立大学法人东京农工大学 2020-11-24 — — CN claimed
WO-2019203296-A1 PREVENTATIVE AND THERAPEUTIC AGENTS FOR SARCOPENIA 国立大学法人東京農工大学 2019-10-24 — — WO claimed
EP-3782648-B1 PROSTAGLANDIN D2 PRODUCTION INHIBITORS AS PREVENTATIVE AND THERAPEUTIC AGENTS FOR SARCOPENIA NATIONAL UNIV CORPORATION TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY (JP) 2024-09-18 — — EP disclosed
US-11883410-B2 Preventative and therapeutic agents for sarcopenia NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLGY (JP) 2024-01-30 — — US disclosed
US-20210161908-A1 PREVENTATIVE AND THERAPEUTIC AGENTS FOR SARCOPENIA NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY (JP) 2021-06-03 — — US disclosed
EP-3782648-A1 PREVENTATIVE AND THERAPEUTIC AGENTS FOR SARCOPENIA National University Corporation Tokyo University of Agriculture and Technology (JP) 2021-02-24 — — EP disclosed
CN-111989119-A Prophylactic and therapeutic agent for sarcopenia 国立大学法人东京农工大学 2020-11-24 — — CN disclosed
WO-2019203296-A1 PREVENTATIVE AND THERAPEUTIC AGENTS FOR SARCOPENIA 国立大学法人東京農工大学 2019-10-24 — — WO disclosed
EP-2407466-B1 PIPERAZINE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHASE TAIHO PHARMACEUTICAL CO LTD (JP) 2016-01-13 — — EP disclosed
US-9062035-B2 Piperazine compound capable of inhibiting prostaglandin D synthase TAIHO PHARMACEUTICAL CO., LTD. (JP) 2015-06-23 — — US disclosed
US-8865714-B2 Piperazine compound capable of inhibiting prostaglandin D synthase TAIHO PHARMACEUTICAL CO., LTD. (JP) 2014-10-21 — — US disclosed
US-20140128394-A1 PIPERAZINE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHASE TAIHO PHARMACEUTICAL CO., LTD. (JP) 2014-05-08 — — US disclosed
EP-2407466-A1 PIPERAZINE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHASE Taiho Pharmaceutical Co., Ltd. (JP) 2012-01-18 — — EP disclosed
US-20110319413-A1 PIPERAZINE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHASE TAIHO PHARMACEUTICAL CO., LTD. (JP) 2011-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11883410-B2 Preventative and therapeutic agents for sarcopenia CPT1B, TNNC1, MTPN HPGDS 32/4885ALDH1A1 1461/4885HPGD 23/4885
US-20140128394-A1 PIPERAZINE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHASE PTGDR, PTGS1, PTGDR2 HPGDS 9/4885ALDH1A1 360/4885HPGD 10/4885
US-20210161908-A1 PREVENTATIVE AND THERAPEUTIC AGENTS FOR SARCOPENIA CPT1B, TNNC1, MTPN HPGDS 32/4885ALDH1A1 1461/4885HPGD 23/4885
US-20110319413-A1 PIPERAZINE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHASE PTGS1, PTGDR, PTGIS HPGDS 10/4885ALDH1A1 257/4885HPGD 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.