Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29530166 | 0.82 | GPR119 (0.52) | GPR119NR1I2CYP3A4CACNA1BSTS | |
| SCHEMBL17948857 | 0.82 | GPR119 (0.52) | GPR119NR1I2CYP3A4CACNA1BSTS | |
| SCHEMBL30833386 | 0.79 | RIPK1 (0.45) | NR1H2NR1H3GPR119STSGHSR | |
| SCHEMBL17942320 | 0.75 | GPR119 (0.52) | GPR119NR1I2CYP3A4CACNA1BSTS | |
| SCHEMBL29530176 | 0.75 | GPR119 (0.52) | GPR119NR1I2CYP3A4CACNA1BSTS | |
| SCHEMBL17942390 | 0.75 | CYP3A4 (0.54) | GPR119NR1I2CYP3A4CACNA1BSTS | |
| SCHEMBL17942445 | 0.74 | CACNA1B (0.53) | NR1I2CYP3A4CACNA1BALDH1A1HTR2A | |
| SCHEMBL18027382 | 0.73 | HTR2A (0.56) | NR1I2CYP3A4CACNA1BHTR2AHTR2C | |
| SCHEMBL30833419 | 0.73 | RIPK1 (0.47) | NR1H2NR1H3GPR119STSHTR2A | |
| SCHEMBL30833494 | 0.73 | NR1H2 (0.45) | NR1H2NR1H3GPR119NR1I2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118164961-A | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-111393414-B | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-111393414-A | 4-methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2020-07-10 | — | — | CN | disclosed |
| CN-107428719-B | 4-methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2020-03-27 | — | — | CN | disclosed |