Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14776637 | 0.80 | SMN1; SMN2 (0.31) | SMN1; SMN2 | |
| SCHEMBL28386162 | 0.78 | SMN1; SMN2 (0.56) | MAPTKDM4ESMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL31218404 | 0.78 | SMN1; SMN2 (0.56) | MAPTKDM4ESMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL31211425 | 0.71 | MAPT (0.43) | MAPTKDM4ECHRM4HPGDHSD17B10 | |
| SCHEMBL31218445 | 0.71 | HSD17B10 (0.36) | MAPTKDM4ECHRM4SMN1; SMN2NQO2 | |
| SCHEMBL28386183 | 0.71 | HSD17B10 (0.36) | MAPTKDM4ECHRM4SMN1; SMN2NQO2 | |
| SCHEMBL13811094 | 0.69 | NPC1 (0.46) | MAPTKDM4ESMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL13734585 | 0.68 | SMN1; SMN2 (0.42) | MAPTKDM4ESMN1; SMN2NQO2NPC1 | |
| SCHEMBL18791317 | 0.64 | ILK (0.34) | — | |
| SCHEMBL10187249 | 0.64 | RAB9A (0.32) | MAPTKDM4ESMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111065626-B | Compounds for the treatment of huntington's disease | PTC医疗公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-111065626-A | Compounds for the treatment of huntington's chorea | PTC医疗公司 | 2020-04-24 | — | — | CN | disclosed |