SCHEMBL28385189

SCHEMBL28385189

Nc1cc2c(cc1N)C(=O)N(c1cccs1)C2=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.37
ALDH1A1 P00352 5/20 0.35
KDM4E B2RXH2 3/20 0.35
MAPT P10636 2/20 0.35
RXFP1 Q9HBX9 1/20 0.35
ANPEP P15144 2/20 0.35
DPP4 P27487 2/20 0.35
KMT2A Q03164 4/20 0.35
USP2 O75604 3/20 0.35
HSD17B10 Q99714 2/20 0.35
MEN1 O00255 2/20 0.35
HSPA1A P0DMV8 1/20 0.34
PABPC1 P11940 1/20 0.34
NPC1 O15118 1/20 0.33
TSHR P16473 1/20 0.33
CASP1 P29466 1/20 0.33
RAB9A P51151 1/20 0.33
CASP7 P55210 1/20 0.33
SCN2A Q99250 1/20 0.33
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL606359 0.81 KMT2A (0.49) ALDH1A1KDM4EMAPTRXFP1KMT2A
SCHEMBL31231930 0.81 KMT2A (0.49) ALDH1A1KDM4EMAPTRXFP1KMT2A
SCHEMBL27822232 0.74 HSD17B10 (0.56) ALDH1A1KDM4EMAPTRXFP1KMT2A
SCHEMBL21474631 0.73 DPP4 (0.37) ALDH1A1KDM4EMAPTDPP4KMT2A
SCHEMBL11591273 0.69 NR1H2 (0.33)
SCHEMBL191887 0.69 TLR9 (0.44) L3MBTL1
SCHEMBL27464474 0.67 NR1I2 (0.39) ALDH1A1KDM4EMAPTKMT2AHSD17B10
SCHEMBL28041068 0.66 KCNH2 (0.61) KCNH2ALDH1A1KDM4EMAPTKMT2A
SCHEMBL10766405 0.64 MAPT (0.37) ALDH1A1KDM4EMAPTKMT2AHSD17B10
SCHEMBL11594002 0.64 MGLL (0.47) ALDH1A1HTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108084409-B Wide-band-gap organic semiconductor material and preparation method and application thereof 华南协同创新研究院 2020-03-24 CN disclosed