SCHEMBL21474631

SCHEMBL21474631

Cc1ccc(C)c2c1C(=O)N(c1cccs1)C2=O

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.37
NR1H2 P55055 1/20 0.33
NR1H3 Q13133 1/20 0.33
ADORA2A P29274 1/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
POLB P06746 3/20 0.32
NPC1 O15118 2/20 0.31
NOTUM Q6P988 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
PKM P14618 1/20 0.31
HPGD P15428 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4597231 0.77 MEN1 (0.35) DPP4NR1H2NR1H3MEN1KMT2A
SCHEMBL31231930 0.75 KMT2A (0.49) MEN1KMT2APOLBKDM4EALDH1A1
SCHEMBL606359 0.75 KMT2A (0.49) MEN1KMT2APOLBKDM4EALDH1A1
SCHEMBL28385189 0.73 KCNH2 (0.37) DPP4ADORA2AMEN1KMT2APOLB
SCHEMBL11591273 0.70 NR1H2 (0.33) NR1H2NR1H3
SCHEMBL20686102 0.70 DPP4 (0.33) DPP4NR1H2NR1H3KDM4EALDH1A1
SCHEMBL191887 0.70 TLR9 (0.44) PKMTDP1L3MBTL1
SCHEMBL21478344 0.69 F2 (0.33) DPP4MEN1KMT2APKM
SCHEMBL13879381 0.69 ALDH1A1 (0.39) MEN1KMT2AKDM4EALDH1A1MAPT
SCHEMBL7412708 0.68 CDK5 (0.43) MEN1KMT2APOLBNPC1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200115482-A1 MIXTURE, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC PRODUCT, POLARIZING PLATE, DISPLAY DEVICE, ANTIREFLECTION FILM, AND PRODUCTION METHOD FOR MIXTURE ZEON CORPORATION (JP) 2020-04-16 US disclosed
US-20200031971-A1 MIXTURE, POLYMERIZABLE COMPOSITION, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC PRODUCT, POLARIZING PLATE, FLAT PANEL DISPLAY DEVICE, ORGANIC ELECTROLUMINESCENT DISPLAY DEVICE, ANTIREFLECTION FILM, AND METHOD OF USING POLYMERIZABLE COMPOUND ZEON CORPORATION (JP) 2020-01-30 US disclosed
US-20190330399-A1 POLYMERIZABLE COMPOUND, MIXTURE, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC BODY, POLARIZER, DISPLAY, AND ANTIREFLECTION FILM ZEON CORPORATION (JP) 2019-10-31 US disclosed
US-20190315893-A1 POLYMERIZABLE COMPOUND, MIXTURE, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC PRODUCT, POLARIZING PLATE, DISPLAY DEVICE, AND ANTIREFLECTION FILM ZEON CORPORATION (JP) 2019-10-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190315893-A1 POLYMERIZABLE COMPOUND, MIXTURE, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC PRODUCT, POLARIZING PLATE, DISPLAY DEVICE, AND ANTIREFLECTION FILM CCNA1, CCNA2, ADRA1A DPP4 4622/4885NR1H2 1234/4885NR1H3 1120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.