Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28175954 | 0.79 | CYP4F2 (0.34) | HSP90AA1HSP90AB1HTR2AHTR2CCYP4F2 | |
| SCHEMBL28387753 | 0.79 | NR1H2 (0.39) | — | |
| SCHEMBL28384779 | 0.78 | NOTUM (0.39) | HTR2AHTR2CKIF11 | |
| SCHEMBL29177383 | 0.78 | KIF11 (0.35) | HTR2AHTR2CCYP4F2CYP4A11KIF11 | |
| SCHEMBL28175953 | 0.73 | HSP90AA1 (0.32) | HSP90AA1HSP90AB1IDO1POLQ | |
| SCHEMBL29059997 | 0.73 | KIF11 (0.40) | HSP90AA1HSP90AB1HTR2ACYP4F2CYP4A11 | |
| SCHEMBL24133311 | 0.72 | KDM4E (0.45) | CYP4F2CYP4A11 | |
| SCHEMBL29071924 | 0.72 | PTGDR2 (0.36) | CYP4F2CYP4A11KIF11 | |
| SCHEMBL2301196 | 0.72 | KIF11 (0.39) | HSP90AA1HSP90AB1HTR2AHTR2CKIF11 | |
| SCHEMBL2964967 | 0.70 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1KIF11IDO1POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107250110-B | Novel compounds as inhibitors of transfection Rearrangement (RET) | 葛兰素史克知识产权发展有限公司 | 2020-04-24 | — | — | CN | disclosed |