Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029794 | 0.79 | NUDT1 (0.42) | GAANUDT1ATRROCK1KDM4E | |
| SCHEMBL18038254 | 0.74 | DYRK1A (0.44) | GSK3BLMNAIRAK4ALDH1A1 | |
| SCHEMBL16572967 | 0.74 | PTPN11 (0.45) | NUDT1GSK3AGSK3BROCK1KDM4E | |
| SCHEMBL107631 | 0.73 | GRM4 (0.45) | GAAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL106399 | 0.72 | GAA (0.40) | GAAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL8281629 | 0.72 | TRPA1 (0.46) | GAAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL106420 | 0.72 | APLNR (0.50) | GAAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1789196 | 0.71 | ROCK1 (0.55) | GAANPC1RAB9AROCK1KDM4E | |
| SCHEMBL12579446 | 0.70 | TRPA1 (0.44) | GAAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL3336071 | 0.70 | HRH4 (0.60) | NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115504986-B | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-115504986-A | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-111094250-B | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-111094250-A | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2020-05-01 | — | — | CN | disclosed |