Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | PTPN4 | P29074 | 2/20 | 0.33 |
| ▸ | PTPN9 | P43378 | 2/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35192 | 0.81 | HTT (0.53) | HTTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL1326156 | 0.81 | HTT (0.41) | HTTCFTRMEN1KMT2AMAPK1 | |
| SCHEMBL19008528 | 0.79 | CFTR (0.52) | HTTCFTRMEN1KMT2AALDH1A1 | |
| SCHEMBL1559114 | 0.77 | HTT (0.45) | HTTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL18955117 | 0.77 | HTT (0.39) | HTTCFTRMEN1KMT2ARAB9A | |
| SCHEMBL28089769 | 0.75 | ALDH1A1 (0.39) | HTTCFTRMEN1KMT2AMAPK1 | |
| Lithium Ion SCHEMBL18939416 | 0.74 | FFAR4 (0.36) | HTTCFTRALDH1A1FFAR4NPSR1 | |
| SCHEMBL2304233 | 0.73 | AOX1 (0.50) | HTTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1203711 | 0.70 | CFTR (0.40) | HTTCFTRMEN1KMT2AALDH1A1 | |
| SCHEMBL27795097 | 0.70 | MEN1 (0.50) | HTTCFTRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115746412-A | Water-soluble chitosan composite hydrogel and preparation method and application thereof | 南方科技大学 | 2023-03-07 | — | — | CN | disclosed |
| CN-113749825-B | Frame type bone joint prosthesis and preparation method and application thereof | 浙江大学 | 2022-08-05 | — | — | CN | disclosed |
| CN-113749825-A | Frame type bone joint prosthesis and preparation method and application thereof | 浙江大学 | 2021-12-07 | — | — | CN | disclosed |
| CN-107286359-B | Hydrogel with heterogeneous multilayer structure and preparation method thereof | 上普博源（北京）生物科技有限公司 | 2020-05-22 | — | — | CN | disclosed |