Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.62 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.62 |
| ▸ | PEPD | P12955 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SLC6A12 | P48065 | 4/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 4/20 | 0.36 |
| ▸ | SLC6A13 | Q9NSD5 | 4/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL5799999 | 0.86 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2PEPDLMNA | |
| Glycine SCHEMBL5158152 | 0.79 | — | — | |
| Glycine SCHEMBL6675874 | 0.79 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL391786 | 0.79 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL13169653 | 0.79 | — | — | |
| Glycine SCHEMBL93765 | 0.79 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL3640989 | 0.79 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL391027 | 0.79 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL6163 | 0.79 | — | — | |
| Glycine SCHEMBL2116443 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111182880-A | WNT compositions and processes performed from serum-free culture conditions | 安卡萨再生疗法公司 | 2020-05-19 | — | — | CN | disclosed |
| CN-110891588-A | Peptidomimetic macrocycles and uses thereof | 艾瑞朗医疗公司 | 2020-03-17 | — | — | CN | disclosed |