Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28642575 | 0.77 | CYP1A2 (0.56) | POLBKDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL19979962 | 0.74 | CYP1A2 (0.46) | POLBKDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL16719847 | 0.74 | KMT2A (0.47) | POLBKDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL28396855 | 0.73 | CYP1A2 (0.57) | POLBKDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL16719335 | 0.73 | MYC (0.58) | POLBKDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL28608913 | 0.71 | POLB (0.41) | POLBKDM4EKMT2AALDH1A1TSHR | |
| SCHEMBL16720403 | 0.71 | OGT (0.45) | KDM4ECYP1A2CYP2C19CYP2C9KMT2A | |
| SCHEMBL1808749 | 0.71 | ALDH1A1 (0.42) | POLBKDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL5869031 | 0.69 | TP53 (0.64) | POLBKDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL3435440 | 0.69 | OPRK1 (0.52) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196804-A | TGF- β R1 inhibitor and application thereof | 南京圣和药业股份有限公司 | 2020-05-26 | — | — | CN | disclosed |