SCHEMBL28407702

SCHEMBL28407702

COc1ccc2c(c1)Cc1ccc3ccccc3c1O2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
CYP2A6 P11509 1/20 0.44
NFKB1 P19838 2/20 0.42
NFKB2 Q00653 2/20 0.42
RELA Q04206 2/20 0.42
DRD2 P14416 7/20 0.42
DRD1 P21728 7/20 0.42
DRD5 P21918 7/20 0.42
DRD3 P35462 7/20 0.42
DRD4 P21917 5/20 0.42
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA4 P22748 2/20 0.41
CA6 P23280 2/20 0.41
ACHE P22303 1/20 0.40
HTR2A P28223 2/20 0.39
KDM4E B2RXH2 1/20 0.39
NPC1 O15118 1/20 0.39
ALDH1A1 P00352 1/20 0.39
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28888914 0.82 CYP1A2 (0.38) CYP1A2CYP2A6ACHEKDM4ENPC1
SCHEMBL28405398 0.79 NFKB1 (0.40) CYP1A2CYP2A6NFKB1NFKB2RELA
SCHEMBL303160 0.78 MAOA (0.55) CYP1A2CYP2A6NFKB1NFKB2RELA
SCHEMBL30396392 0.77 DRD2 (0.50) DRD2DRD1DRD5DRD3DRD4
SCHEMBL5757673 0.76 MAOA (0.59) DRD2DRD1DRD5DRD3DRD4
SCHEMBL10378225 0.75 HSD17B10 (0.46) CYP1A2CYP2A6NFKB1NFKB2RELA
SCHEMBL30779751 0.75 HSD17B10 (0.46) CYP1A2CYP2A6NFKB1NFKB2RELA
SCHEMBL28394024 0.74 CYP2A6 (0.39) CYP1A2CYP2A6ACHEKDM4ENPC1
SCHEMBL28407698 0.73 MAPT (0.44) NFKB1NFKB2RELAACHEHTR2A
SCHEMBL10378227 0.73 KDM4E (0.54) CYP1A2CYP2A6NFKB1NFKB2RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057037-B Ultraviolet light-promoted synthesis method of xanthone compound 浙江工业大学 2021-07-23 CN disclosed
CN-111057037-A Ultraviolet light-promoted synthesis method of xanthone compound 浙江工业大学 2020-04-24 CN disclosed