Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4197867 | 0.90 | — | — | |
| Succinic Acid SCHEMBL27825761 | 0.83 | TSHR (0.37) | TSHRLMNAALKBH5SUCNR1EGLN1 | |
| SCHEMBL28618910 | 0.81 | TSHR (0.36) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| Succinic Acid SCHEMBL27609721 | 0.79 | TSHR (0.41) | TSHRLMNAALKBH5SUCNR1EGLN1 | |
| SCHEMBL20957533 | 0.79 | TSHR (0.34) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL28356995 | 0.79 | TSHR (0.38) | TSHRLMNAALKBH5SUCNR1EGLN1 | |
| Succinic Acid SCHEMBL4197612 | 0.78 | TSHR (0.44) | TSHRLMNAALKBH5SUCNR1EGLN1 | |
| Succinic Acid SCHEMBL27731906 | 0.77 | ALDH1A1 (0.38) | TSHRLMNAALKBH5SUCNR1EGLN1 | |
| SCHEMBL1104277 | 0.75 | EGLN1 (0.41) | TSHRLMNAALKBH5SUCNR1EGLN1 | |
| SCHEMBL8965849 | 0.74 | TSHR (0.41) | TSHRLMNAALDH1A1TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106796408-B | Conductive member, conductive roller, and image forming apparatus | 株式会社普利司通 | 2020-06-12 | — | — | CN | disclosed |