Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of P-Cresol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroquinone SCHEMBL11759332 | 0.87 | ALDH1A1 (0.57) | ALDH1A1KDM4ETAAR1L3MBTL1BACE1 | |
| P-Cresol SCHEMBL9478964 | 0.83 | ACHE (0.62) | ACHEALDH1A1KDM4ETAAR1L3MBTL1 | |
| P-Cresol SCHEMBL8158679 | 0.81 | ACHE (0.77) | ACHEALDH1A1KDM4EL3MBTL1CYP1A2 | |
| P-Cresol SCHEMBL1127979 | 0.81 | ACHE (0.87) | ACHEALDH1A1KDM4EL3MBTL1CYP1A2 | |
| P-Xylene SCHEMBL28199191 | 0.81 | ACHE (1.00) | ACHEALDH1A1KDM4EL3MBTL1CYP1A2 | |
| P-Cresol SCHEMBL375 | 0.81 | — | — | |
| P-Cresol SCHEMBL11263098 | 0.81 | ACHE (1.00) | ACHEALDH1A1KDM4EL3MBTL1CYP1A2 | |
| P-Cresol SCHEMBL9726112 | 0.81 | ACHE (1.00) | ACHEALDH1A1KDM4EL3MBTL1CYP1A2 | |
| P-Cresol SCHEMBL960690 | 0.81 | ACHE (1.00) | ACHEALDH1A1KDM4EL3MBTL1CYP1A2 | |
| P-Cresol SCHEMBL29774950 | 0.79 | ACHE (0.56) | ACHEALDH1A1KDM4ETAAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269328-A | Temperature response type eutectic solvent and extraction method of ganoderma lucidum polysaccharide | 中国农业科学院麻类研究所 | 2020-06-12 | — | — | CN | disclosed |