Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydroquinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.57 |
| ▸ | HTR3A | P46098 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | ABAT | P80404 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA3 | P07451 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Cresol SCHEMBL28410048 | 0.87 | ACHE (0.65) | ALDH1A1KDM4ETAAR1HTR3AL3MBTL1 | |
| Phenol SCHEMBL1029320 | 0.85 | TDP1 (0.61) | ALDH1A1KDM4ETAAR1HTR3AL3MBTL1 | |
| Phenol SCHEMBL1833685 | 0.85 | TDP1 (0.61) | ALDH1A1KDM4ETAAR1HTR3AL3MBTL1 | |
| Hydroquinone SCHEMBL15514721 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4ETAAR1HTR3AL3MBTL1 | |
| Hydroquinone SCHEMBL10547720 | 0.82 | ALDH1A1 (0.67) | ALDH1A1KDM4EL3MBTL1ADRA2ASLC6A2 | |
| Phenol SCHEMBL1335365 | 0.79 | TDP1 (0.52) | ALDH1A1KDM4ETAAR1HTR3AL3MBTL1 | |
| Hydroquinone SCHEMBL11351098 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KDM4ETAAR1HTR3AL3MBTL1 | |
| Hydroquinone SCHEMBL9150249 | 0.76 | ALDH1A1 (0.57) | ALDH1A1KDM4EL3MBTL1ADRA2ASLC6A2 | |
| Catechol SCHEMBL2279087 | 0.75 | ALDH1A1 (0.59) | ALDH1A1KDM4ETAAR1L3MBTL1HTR1A | |
| Hydroquinone SCHEMBL6012111 | 0.73 | CA12 (0.80) | ALDH1A1KDM4ETAAR1HTR3AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4038390-A | SALTS OF P-DIHYDROXYBENZENE DISULFONIC ACIDS FOR COMBATTING HEMORRHAGES AND FRAGILITY OF THE CAPILLARIES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1977-07-26 | — | — | US | claimed |
| US-4038390-A | SALTS OF P-DIHYDROXYBENZENE DISULFONIC ACIDS FOR COMBATTING HEMORRHAGES AND FRAGILITY OF THE CAPILLARIES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1977-07-26 | — | — | US | disclosed |
| US-3947448-A | BLOOD COAGULANT, COMBATING CAPILLARY FRAGILITY | LABORATORIOS DEL DR. ESTEVE SA (ES) | 1976-03-30 | — | — | US | disclosed |