Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877163 | 0.90 | RAB9A (0.43) | L3MBTL1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4132243 | 0.80 | RIPK1 (0.49) | MEN1KMT2ATSHRRIPK1ALDH1A1 | |
| SCHEMBL11708369 | 0.77 | KDM4E (0.66) | L3MBTL1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL20646025 | 0.77 | CHRM2 (0.47) | L3MBTL1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL18366270 | 0.77 | CHRM2 (0.47) | L3MBTL1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL13225803 | 0.77 | KDM4E (0.66) | L3MBTL1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3739324 | 0.76 | HDAC6 (0.54) | L3MBTL1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5837860 | 0.75 | L3MBTL1 (0.58) | L3MBTL1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2456072 | 0.74 | CHRM2 (0.44) | L3MBTL1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL24508712 | 0.74 | CHRM2 (0.55) | L3MBTL1CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110023313-B | Bicyclic amide compounds and methods of use thereof | 豪夫迈·罗氏有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-110072863-B | RIP1 kinase inhibitors and methods of use | 豪夫迈·罗氏有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-110914271-A | Bicyclic ketone compounds and methods of use thereof | 豪夫迈·罗氏有限公司 | 2020-03-24 | — | — | CN | disclosed |