Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 7/20 | 0.40 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28417785 | 0.85 | CREBBP (0.44) | CREBBPEPHB3BRD2BRD3EP300 | |
| SCHEMBL28411099 | 0.85 | KDM4E (0.44) | CREBBPEPHB3BRD2BRD3EP300 | |
| SCHEMBL28416810 | 0.84 | ABCB1 (0.45) | CREBBPCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL28881175 | 0.83 | CREBBP (0.57) | CREBBPEPHB3BRD2BRD3BAZ2B | |
| SCHEMBL28415697 | 0.82 | CREBBP (0.58) | CREBBPEPHB3BRD2BRD3EP300 | |
| SCHEMBL28418305 | 0.80 | CREBBP (0.43) | CREBBPEPHB3BRD2BRD3EP300 | |
| SCHEMBL28422565 | 0.80 | LCLAT1 (0.40) | CREBBPEPHB3CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28891091 | 0.80 | CREBBP (0.41) | CREBBPEPHB3BRD2BRD3EP300 | |
| SCHEMBL28415713 | 0.80 | CREBBP (0.46) | CREBBPEPHB3BRD2BRD3EP300 | |
| SCHEMBL28419951 | 0.79 | SMN1; SMN2 (0.39) | CREBBPEPHB3BRD2BRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111320621-A | Indolizine compound and preparation method and application thereof | 中国科学院广州生物医药与健康研究院 | 2020-06-23 | — | — | CN | disclosed |