SCHEMBL28418656

SCHEMBL28418656

COc1ccc(OC(=O)C(C(=O)c2ccc(OC)cc2)c2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.56
NPC1 O15118 3/20 0.56
RAB9A P51151 3/20 0.56
POLB P06746 2/20 0.56
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
ALDH1A1 P00352 5/20 0.53
NPSR1 Q6W5P4 2/20 0.52
CES2 O00748 1/20 0.51
CES1 P23141 1/20 0.51
PAX8 Q06710 1/20 0.51
LMNA P02545 3/20 0.50
MITF O75030 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
HIF1A Q16665 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.49
CYP1A2 P05177 1/20 0.49
ELANE P08246 1/20 0.49
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5217880 0.89 MAPT (0.63) MAPTNPC1RAB9APOLBMEN1
SCHEMBL3062323 0.84 KMT2A (0.60) MAPTNPC1RAB9APOLBKMT2A
SCHEMBL15665536 0.81 CA1 (0.52) MAPTNPC1RAB9APOLBMEN1
SCHEMBL5215589 0.80 CES2 (0.57) MAPTNPC1RAB9APOLBMEN1
SCHEMBL6642403 0.80 NPC1 (0.63) MAPTNPC1RAB9APOLBMEN1
SCHEMBL7093345 0.79 NPC1 (0.56) MAPTNPC1RAB9APOLBMEN1
SCHEMBL7560417 0.79 L3MBTL1 (0.66) MAPTNPC1RAB9APOLBMEN1
SCHEMBL23674188 0.78 NPC1 (0.61) MAPTNPC1RAB9APOLBMEN1
SCHEMBL28419390 0.78 ELANE (0.55) MAPTNPC1RAB9APOLBMEN1
SCHEMBL812736 0.78 LMNA (0.67) MAPTNPC1RAB9APOLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110029356-B method for preparing ketone or β -carbonyl ester controlled by electrochemical oxidation method 北京大学 2020-06-02 CN disclosed