SCHEMBL7560417

SCHEMBL7560417

COc1ccc(C(=O)C(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.66
TDP1 Q9NUW8 1/20 0.66
POLB P06746 2/20 0.63
MAPT P10636 2/20 0.63
NPC1 O15118 2/20 0.63
RAB9A P51151 2/20 0.63
MEN1 O00255 1/20 0.63
KMT2A Q03164 1/20 0.63
CES2 O00748 1/20 0.59
CES1 P23141 1/20 0.59
NPSR1 Q6W5P4 2/20 0.58
ALDH1A1 P00352 6/20 0.56
LMNA P02545 2/20 0.56
MITF O75030 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
HIF1A Q16665 1/20 0.56
CYP1A2 P05177 1/20 0.56
KLK7 P49862 3/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2922278 0.95 L3MBTL1 (0.69) L3MBTL1TDP1POLBMAPTNPC1
SCHEMBL2921669 0.93 L3MBTL1 (0.66) L3MBTL1TDP1POLBMAPTNPC1
SCHEMBL16807279 0.91 HPGD (0.57) L3MBTL1TDP1POLBMAPTNPC1
SCHEMBL16807286 0.87 NPSR1 (0.60) L3MBTL1TDP1POLBMAPTNPC1
SCHEMBL5217880 0.86 MAPT (0.63) L3MBTL1POLBMAPTNPC1RAB9A
SCHEMBL29262742 0.84 LMNA (0.67) L3MBTL1POLBMAPTNPC1RAB9A
SCHEMBL4604321 0.84 MAPT (0.61) L3MBTL1POLBMAPTNPC1RAB9A
SCHEMBL812736 0.84 LMNA (0.67) L3MBTL1POLBMAPTNPC1RAB9A
SCHEMBL4604318 0.84 MAPT (0.61) L3MBTL1POLBMAPTNPC1RAB9A
SCHEMBL31266975 0.84 POLB (0.48) L3MBTL1TDP1POLBMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110891961-B Improved process for the preparation of imaelstat 美国杰龙生物医药公司 2023-06-30 CN claimed
US-5789576-A DIASTEREOSPECIFIC DIMERIZATION USING ALKOXYMAGNESIUM HALIDE REACTANT; USED FOR SOLID PHASE SYNTHESIS OF ANTISENSE OLIGONUCLEOTIDES GENTA INCORPORATED (US) 1998-08-04 US claimed
US-5166330-A Phosphonation, amination and reaction with nucleosides HOECHST AKTIENGESELLSCHAFT (DE) 1992-11-24 US claimed
EP-0136543-B1 METHOD FOR THE PREPARATION OF NUCLEOSIDEALKYL, ARALKYL AND ARYL PHOSPHONITES AND PHOSPHONATES HOECHST AKTIENGESELLSCHAFT (DE) 1988-11-23 EP claimed
EP-0136543-A2 Method for the preparation of nucleosidealkyl, aralkyl and aryl phosphonites and phosphonates HOECHST AKTIENGESELLSCHAFT (DE) 1985-04-10 EP claimed
CN-117357548-A Oligonucleotide composition and method for preparing same 美国杰龙生物医药公司 2024-01-09 CN disclosed
CN-111228288-B Oligonucleotide composition and method for preparing same 美国杰龙生物医药公司 2023-10-20 CN disclosed
EP-0850248-B1 COMPOSITIONS AND METHODS FOR THE SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES POLSKA AKAD NAUK CENTRUM (PL) 2002-07-24 EP disclosed
US-20020068275-A1 METHODS OF USING A CHIMERIC NUCLEIC ACID/NUCLEIC ACID ANALOGUE MOLECULE AMERSHAM INTERNATIONAL PLC (GB) 2002-06-06 US disclosed
EP-0720615-B1 ELONGATION, AMPLIFICATION AND SEQUENCE DETERMINATION USING A CHIMERIC OLIGONUCLEOTIDE AMERSHAM PHARM BIOTECH UK LTD (GB) 2000-07-26 EP disclosed
US-5856465-A NUCLEOSIDE INTERMEDIATES POLSKA AKADEMIA NAUK CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH (PL) 1999-01-05 US disclosed
US-5789576-A DIASTEREOSPECIFIC DIMERIZATION USING ALKOXYMAGNESIUM HALIDE REACTANT; USED FOR SOLID PHASE SYNTHESIS OF ANTISENSE OLIGONUCLEOTIDES GENTA INCORPORATED (US) 1998-08-04 US disclosed
EP-0850248-A1 COMPOSITIONS AND METHODS FOR THE SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES POLSKA AKADEMIA NAUK CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH (PL) 1998-07-01 EP disclosed
WO-1997009340-A1 COMPOSITIONS AND METHODS FOR THE SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES POLSKA AKADEMIA NAUK CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH (PL) 1997-03-13 WO disclosed
EP-0720615-A1 REAGENTS COMPRISING CHIMERIC MOLECULES OF NUCLEIC ACIDS AND NUCLEIC ACID ANALOGS AMERSHAM INTERNATIONAL plc (GB) 1996-07-10 EP disclosed
WO-1995008556-A1 REAGENTS COMPRISING CHIMERIC MOLECULES OF NUCLEIC ACIDS AND NUCLEIC ACID ANALOGS AMERSHAM INTERNATIONAL PLC (GB) 1995-03-30 WO disclosed
US-5166330-A Phosphonation, amination and reaction with nucleosides HOECHST AKTIENGESELLSCHAFT (DE) 1992-11-24 US disclosed
EP-0136543-B1 METHOD FOR THE PREPARATION OF NUCLEOSIDEALKYL, ARALKYL AND ARYL PHOSPHONITES AND PHOSPHONATES HOECHST AKTIENGESELLSCHAFT (DE) 1988-11-23 EP disclosed
EP-0136543-A2 Method for the preparation of nucleosidealkyl, aralkyl and aryl phosphonites and phosphonates HOECHST AKTIENGESELLSCHAFT (DE) 1985-04-10 EP disclosed