SCHEMBL28428243

SCHEMBL28428243

O=C(Nc1nc(-c2ccccc2)cn1-c1ccccc1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 6/20 0.56
TMIGD3 P0DMS9 5/20 0.56
ADORA1 P30542 3/20 0.52
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
GRM5 P41594 1/20 0.52
MAPK1 P28482 1/20 0.51
MAPT P10636 2/20 0.49
LMNA P02545 2/20 0.49
KDM4E B2RXH2 1/20 0.49
ALDH1A1 P00352 1/20 0.48
CXCR5 P32302 1/20 0.48
APLNR P35414 1/20 0.48
CCR6 P51684 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8038965 0.94 TMIGD3 (0.50) ADORA3TMIGD3ADORA1NPC1RAB9A
SCHEMBL8032750 0.91 ADORA3 (0.49) ADORA3TMIGD3ADORA1NPC1RAB9A
SCHEMBL8039049 0.89 TMIGD3 (0.45) ADORA3TMIGD3ADORA1NPC1RAB9A
SCHEMBL8038333 0.89 ALDH1A1 (0.53) ADORA3TMIGD3NPC1RAB9AGRM5
SCHEMBL8021617 0.89 TMIGD3 (0.45) ADORA3TMIGD3ADORA1NPC1RAB9A
SCHEMBL8039052 0.89 HDAC1 (0.46) ADORA3TMIGD3ADORA1NPC1RAB9A
SCHEMBL8034915 0.89 MAPT (0.46) ADORA3TMIGD3ADORA1NPC1RAB9A
SCHEMBL8038395 0.88 ALDH1A1 (0.52) ADORA3TMIGD3NPC1RAB9AGRM5
SCHEMBL8038398 0.88 TMIGD3 (0.46) ADORA3TMIGD3ADORA1NPC1RAB9A
SCHEMBL8030835 0.85 USP2 (0.50) ADORA3TMIGD3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110396116-B [ N, O ] bidentate nickel and palladium complex of ketone-imidazoline-2-imine ligand, and preparation method and application thereof 东华大学 2020-07-28 CN disclosed