Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.55 |
| ▸ | EGFR | P00533 | 8/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.50 |
| ▸ | KRAS | P01116 | 1/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 4/20 | 0.47 |
| ▸ | MST1R | Q04912 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | TEK | Q02763 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | FGR | P09769 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28426786 | 0.86 | SRC (0.57) | SRCTGFBR1KRASSOS1MET | |
| SCHEMBL28427821 | 0.81 | MET (0.48) | SRCKRASSOS1METMST1R | |
| SCHEMBL30646048 | 0.81 | PDGFRA (0.50) | SRCKRASSOS1METMST1R | |
| SCHEMBL28428914 | 0.80 | PDGFRA (0.49) | SRCKRASSOS1METMST1R | |
| SCHEMBL28420947 | 0.79 | KDR (0.51) | SRCEGFRERBB2KRASSOS1 | |
| SCHEMBL25130670 | 0.79 | KRAS (0.53) | EGFRERBB2KRASSOS1MET | |
| SCHEMBL30292605 | 0.79 | KRAS (0.53) | EGFRERBB2KRASSOS1MET | |
| SCHEMBL30646019 | 0.78 | PDGFRA (0.62) | SRCKRASSOS1METMST1R | |
| SCHEMBL29111053 | 0.78 | PDGFRA (0.62) | SRCKRASSOS1METMST1R | |
| SCHEMBL28423297 | 0.78 | PDGFRA (0.52) | SRCMETMST1RKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253385-B | Heterocyclic compound, preparation method and application | 遵义医科大学珠海校区 | 2023-11-24 | — | — | CN | disclosed |
| CN-111253385-A | Heterocyclic compound, preparation method and application | 遵义医科大学珠海校区 | 2020-06-09 | — | — | CN | disclosed |