Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28435371 | 0.81 | LGMN (0.49) | ALDH1A1LMNASMN1; SMN2PLA2G1BGAA | |
| SCHEMBL28451619 | 0.80 | MAPK9 (0.48) | ALDH1A1LMNASMN1; SMN2TSHRMCOLN3 | |
| SCHEMBL28441103 | 0.75 | MAPK9 (0.47) | ALDH1A1LMNASMN1; SMN2TSHRMCOLN3 | |
| SCHEMBL28440872 | 0.74 | JAK2 (0.48) | ALDH1A1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL29670005 | 0.71 | JAK2 (0.60) | — | |
| SCHEMBL14221236 | 0.69 | PLK1 (0.55) | — | |
| SCHEMBL28443652 | 0.69 | JAK2 (0.64) | ALDH1A1LMNASMN1; SMN2TSHRMTOR | |
| SCHEMBL28445171 | 0.69 | PIK3R1 (0.49) | ALDH1A1SMN1; SMN2TSHRMTORMAPK9 | |
| SCHEMBL28442722 | 0.68 | FGFR4 (0.71) | MAPK9MAPK10 | |
| SCHEMBL28442021 | 0.66 | POLB (0.45) | ALDH1A1LMNASMN1; SMN2TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |