Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.50 |
| ▸ | JAK3 | P52333 | 5/20 | 0.50 |
| ▸ | JAK1 | P23458 | 4/20 | 0.50 |
| ▸ | TYK2 | P29597 | 4/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 5/20 | 0.46 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437346 | 0.88 | JAK2 (0.64) | JAK2JAK3JAK1TYK2MAPK9 | |
| SCHEMBL28447910 | 0.87 | JAK3 (0.65) | JAK2JAK3JAK1TYK2MAPK9 | |
| SCHEMBL28441100 | 0.84 | JAK2 (0.61) | JAK2JAK3JAK1TYK2MAPK9 | |
| SCHEMBL28441103 | 0.83 | MAPK9 (0.47) | JAK2JAK3JAK1TYK2MAPK9 | |
| SCHEMBL28437336 | 0.83 | JAK2 (0.47) | JAK2JAK3JAK1TYK2MAPK9 | |
| SCHEMBL28437334 | 0.80 | JAK2 (0.42) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL24426201 | 0.77 | JAK2 (0.64) | JAK2JAK3JAK1TYK2MAPK9 | |
| SCHEMBL24426203 | 0.76 | JAK2 (0.63) | JAK2JAK3JAK1TYK2MAPK9 | |
| SCHEMBL28443652 | 0.75 | JAK2 (0.64) | JAK2JAK3FLT3ALDH1A1POLB | |
| SCHEMBL28447917 | 0.75 | MAPK9 (0.44) | JAK2JAK3JAK1TYK2MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |