Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | STAT6 | P42226 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28447917 | 0.89 | MAPK9 (0.44) | JAK2JAK3STAT6FLT3FGFR4 | |
| SCHEMBL28437348 | 0.86 | JAK2 (0.64) | JAK2JAK3FLT3FGFR4JAK1 | |
| SCHEMBL28441103 | 0.84 | MAPK9 (0.47) | JAK2JAK3STAT6FGFR4JAK1 | |
| SCHEMBL28437333 | 0.83 | JAK2 (0.50) | JAK2JAK3STAT6FLT3JAK1 | |
| SCHEMBL28441100 | 0.81 | JAK2 (0.61) | JAK2JAK3STAT6FLT3JAK1 | |
| SCHEMBL28439360 | 0.77 | JAK2 (0.63) | JAK2JAK3FLT3FGFR4JAK1 | |
| SCHEMBL28441098 | 0.76 | JAK2 (0.61) | JAK2FLT3FGFR4ROS1ALK | |
| SCHEMBL28447910 | 0.74 | JAK3 (0.65) | JAK2JAK3JAK1TYK2CSF1R | |
| SCHEMBL28442021 | 0.74 | POLB (0.45) | STAT6TYK2PIK3CDPIK3CGMAPK9 | |
| SCHEMBL22860801 | 0.71 | JAK2 (0.82) | JAK2JAK3FLT3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |