Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23917206 | 0.78 | NOTUM (0.43) | NOTUMMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL27852096 | 0.76 | NOTUM (0.75) | NOTUMDRD2DRD4MEN1KMT2A | |
| SCHEMBL14294095 | 0.76 | NOTUM (1.00) | NOTUMDRD2DRD4MEN1KMT2A | |
| SCHEMBL28449731 | 0.72 | NOTUM (0.39) | NOTUMDRD2DRD4MEN1KMT2A | |
| SCHEMBL7550236 | 0.72 | NOTUM (0.69) | NOTUMDRD2DRD4MEN1KMT2A | |
| SCHEMBL23917530 | 0.69 | ALDH1A1 (0.44) | NOTUMMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL28455660 | 0.69 | NOTUM (0.70) | NOTUMDRD2DRD4MEN1KMT2A | |
| SCHEMBL8016162 | 0.69 | NOTUM (0.63) | NOTUMDRD2DRD4MEN1KMT2A | |
| SCHEMBL1868992 | 0.69 | NOTUM (0.58) | NOTUMDRD2DRD4MEN1KMT2A | |
| SCHEMBL8208943 | 0.68 | DRD2 (0.65) | NOTUMDRD2DRD4TP53AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111892579-B | Kinase inhibitors | 上海艾力斯医药科技股份有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-111875585-B | Kinase inhibitors | 上海艾力斯医药科技股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-111892579-A | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-11-06 | — | — | CN | disclosed |
| CN-111875585-A | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-106660993-B | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-09-11 | — | — | CN | disclosed |