Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28444902 | 0.89 | CYP1A2 (0.47) | CYP11B2MAPK1CYP1A2POLBCYP3A4 | |
| SCHEMBL28453066 | 0.75 | CYP1A2 (0.50) | CYP1A2POLBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12103642 | 0.71 | AOC3 (0.50) | CYP1A2POLBCYP3A4CYP2C9CYP2C19 | |
| Benzonitrile SCHEMBL29165371 | 0.70 | CYP11B2 (0.79) | CYP11B2CYP1A2CYP3A4CYP11B1CYP19A1 | |
| SCHEMBL30712752 | 0.70 | CYP11B2 (1.00) | CYP11B2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6188982 | 0.70 | CYP11B2 (1.00) | CYP11B2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12103615 | 0.70 | AOC3 (0.49) | CYP11B2CYP1A2POLBCYP3A4CYP2C9 | |
| SCHEMBL25682800 | 0.69 | CYP11B2 (0.54) | CYP11B2CYP11B1CYP19A1CYP17A1NPY5R | |
| SCHEMBL12103625 | 0.69 | AOC3 (0.46) | CYP11B2CYP1A2POLBCYP3A4CYP2C9 | |
| SCHEMBL24620491 | 0.68 | CYP11B2 (0.59) | CYP11B2MAPK1CYP11B1CYP19A1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109799298-B | Detection method of related substances in Perampanel bulk drug | 南京海纳医药科技股份有限公司 | 2022-01-07 | — | — | CN | claimed |
| CN-109342603-B | Detection method of perampanel tablet related substances | 南京海纳医药科技股份有限公司 | 2020-08-21 | — | — | CN | claimed |
| CN-109799298-B | Detection method of related substances in Perampanel bulk drug | 南京海纳医药科技股份有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-109342603-B | Detection method of perampanel tablet related substances | 南京海纳医药科技股份有限公司 | 2020-08-21 | — | — | CN | disclosed |