SCHEMBL28444902

SCHEMBL28444902

N#Cc1cccc(-c2ccc(-c3cccnc3)n(-c3ccccc3)c2=O)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.47
CYP3A4 P08684 3/20 0.47
CYP2C19 P33261 3/20 0.47
POLB P06746 1/20 0.47
CYP2C9 P11712 1/20 0.47
CHRNB2 P17787 2/20 0.47
CHRNA5 P30532 2/20 0.47
CHRNA4 P43681 2/20 0.47
CYP11B2 P19099 5/20 0.44
CYP11B1 P15538 4/20 0.44
CYP19A1 P11511 1/20 0.44
MAPK1 P28482 2/20 0.44
KCNA5 P22460 2/20 0.43
KCNH2 Q12809 2/20 0.43
OXTR P30559 1/20 0.42
AVPR1A P37288 1/20 0.42
NEK1 Q96PY6 1/20 0.42
SLC22A12 Q96S37 1/20 0.41
CYP17A1 P05093 1/20 0.41
ALDH1A1 P00352 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28446348 0.89 CYP11B2 (0.51) CYP1A2CYP3A4CYP2C19POLBCYP2C9
SCHEMBL28453066 0.74 CYP1A2 (0.50) CYP1A2CYP3A4CYP2C19POLBCYP2C9
SCHEMBL29809001 0.72 CYP11B2 (0.71) CYP1A2CYP3A4CYP2C19CHRNB2CHRNA5
SCHEMBL13537172 0.72 CYP11B2 (0.71) CYP1A2CYP3A4CYP2C19CHRNB2CHRNA5
SCHEMBL27812115 0.69 GRM5 (0.63) CYP1A2CYP3A4CYP2C19CYP2C9CHRNB2
SCHEMBL27832171 0.69 GRM5 (0.62) CHRNB2CHRNA5CHRNA4CYP11B2CYP11B1
Benzonitrile SCHEMBL29165371 0.69 CYP11B2 (0.79) CYP1A2CYP3A4CHRNB2CHRNA5CHRNA4
SCHEMBL2398328 0.68 GRM5 (0.62) CHRNB2CHRNA5CHRNA4CYP11B2CYP11B1
SCHEMBL16558140 0.67 CYP11B2 (0.45) CHRNB2CHRNA5CHRNA4CYP11B2CYP11B1
SCHEMBL16561064 0.67 CYP11B2 (0.45) CHRNB2CHRNA5CHRNA4CYP11B2CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109799298-B Detection method of related substances in Perampanel bulk drug 南京海纳医药科技股份有限公司 2022-01-07 CN claimed
CN-109342603-B Detection method of perampanel tablet related substances 南京海纳医药科技股份有限公司 2020-08-21 CN claimed
CN-109799298-B Detection method of related substances in Perampanel bulk drug 南京海纳医药科技股份有限公司 2022-01-07 CN disclosed
CN-109342603-B Detection method of perampanel tablet related substances 南京海纳医药科技股份有限公司 2020-08-21 CN disclosed