Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.39 |
| ▸ | DHPS | P49366 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29504659 | 0.80 | HTT (0.56) | CYP1A2CYP3A4HTTKMT2ADHODH | |
| SCHEMBL1173860 | 0.80 | HTT (0.56) | CYP1A2CYP3A4HTTKMT2ADHODH | |
| SCHEMBL30335331 | 0.80 | HTT (0.56) | CYP1A2CYP3A4HTTKMT2ADHODH | |
| SCHEMBL28446348 | 0.75 | CYP11B2 (0.51) | CYP1A2CYP3A4CYP2C9CYP2C19POLB | |
| SCHEMBL9894437 | 0.75 | MAPT (0.50) | CYP1A2CYP3A4CYP2C9CYP2C19POLB | |
| SCHEMBL28444902 | 0.74 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C9CYP2C19POLB | |
| SCHEMBL10968862 | 0.70 | HTT (0.54) | CYP1A2CYP3A4HTTKMT2ADHODH | |
| Pyridine SCHEMBL9227339 | 0.70 | ALDH1A1 (0.58) | POLBHTTKMT2ARECQLALDH1A1 | |
| SCHEMBL12103642 | 0.69 | AOC3 (0.50) | CYP1A2CYP3A4CYP2C9CYP2C19POLB | |
| SCHEMBL12103636 | 0.68 | DHODH (0.48) | CYP1A2CYP3A4CYP2C9CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109799298-B | Detection method of related substances in Perampanel bulk drug | 南京海纳医药科技股份有限公司 | 2022-01-07 | — | — | CN | claimed |
| CN-109342603-B | Detection method of perampanel tablet related substances | 南京海纳医药科技股份有限公司 | 2020-08-21 | — | — | CN | claimed |
| CN-109799298-B | Detection method of related substances in Perampanel bulk drug | 南京海纳医药科技股份有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-109342603-B | Detection method of perampanel tablet related substances | 南京海纳医药科技股份有限公司 | 2020-08-21 | — | — | CN | disclosed |