Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.34 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17339091 | 0.80 | CDK2 (0.46) | DYRK1AGSK3BCDC7CDK2KDM4E | |
| SCHEMBL29037102 | 0.74 | ABCG2 (0.34) | CDC7CDK2BAZ2BBAZ2ABRD4 | |
| SCHEMBL29037101 | 0.73 | PRMT5 (0.43) | CDC7CDK2BAZ2BBAZ2ABRD4 | |
| SCHEMBL15197020 | 0.69 | BAZ2B (0.43) | BAZ2BBAZ2A | |
| SCHEMBL24031008 | 0.69 | DYRK1A (0.37) | DYRK1AGSK3BKCNH2CDC7AAK1 | |
| SCHEMBL30161365 | 0.69 | DYRK1A (0.37) | DYRK1AGSK3BKCNH2CDC7AAK1 | |
| SCHEMBL25635441 | 0.67 | DYRK1A (0.38) | DYRK1AGSK3BKCNH2CDC7BRD4 | |
| SCHEMBL15158136 | 0.66 | KDM4E (0.41) | GSK3BKDM4EALDH1A1GAAGLA | |
| SCHEMBL15196988 | 0.66 | ALDH1A1 (0.53) | KDM4EALDH1A1GAAGLAMAPT | |
| SCHEMBL25416552 | 0.66 | KDM4E (0.53) | DYRK1AKHKCDK2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111892579-B | Kinase inhibitors | 上海艾力斯医药科技股份有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-111875585-B | Kinase inhibitors | 上海艾力斯医药科技股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-111892579-A | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-11-06 | — | — | CN | disclosed |
| CN-111875585-A | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-106660993-B | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-09-11 | — | — | CN | disclosed |