Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 6/20 | 0.64 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8163634 | 0.98 | DNM1 (0.62) | DNM1ZDHHC20HCAR2ALDH1A1TSHR | |
| Maleic Acid SCHEMBL8163631 | 0.98 | DNM1 (0.62) | DNM1ZDHHC20HCAR2ALDH1A1TSHR | |
| Bicarbonate SCHEMBL28289848 | 0.85 | DNM1 (0.75) | DNM1ALDH1A1TSHRMEN1KMT2A | |
| Bicarbonate SCHEMBL4389120 | 0.85 | DNM1 (0.75) | DNM1ALDH1A1TSHRMEN1KMT2A | |
| Bicarbonate SCHEMBL27740162 | 0.85 | DNM1 (0.75) | DNM1ALDH1A1TSHRMEN1KMT2A | |
| Bicarbonate SCHEMBL1689392 | 0.85 | DNM1 (0.75) | DNM1ALDH1A1TSHRMEN1KMT2A | |
| Bicarbonate SCHEMBL30524909 | 0.85 | DNM1 (0.75) | DNM1ALDH1A1TSHRMEN1KMT2A | |
| Bicarbonate SCHEMBL4389117 | 0.85 | DNM1 (0.75) | DNM1ALDH1A1TSHRMEN1KMT2A | |
| Bicarbonate SCHEMBL414156 | 0.85 | DNM1 (0.75) | DNM1ALDH1A1TSHRMEN1KMT2A | |
| Bicarbonate SCHEMBL27083091 | 0.85 | DNM1 (0.75) | DNM1ALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471485-B | Method for removing sodium salt from hydrocarbon oil | 中国石油化工股份有限公司 | 2021-12-17 | — | — | CN | disclosed |
| CN-111471485-A | Method for removing sodium salt from hydrocarbon oil | 中国石油化工股份有限公司 | 2020-07-31 | — | — | CN | disclosed |