Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 8/20 | 0.68 |
| ▸ | ABHD6 | Q9BV23 | 8/20 | 0.68 |
| ▸ | PLA2G7 | Q13093 | 6/20 | 0.68 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | VEGFA | P15692 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30141417 | 1.00 | MGLL (0.68) | MGLLABHD6PLA2G7TRPV1CHRM2 | |
| SCHEMBL5335100 | 0.95 | PLA2G7 (0.61) | MGLLABHD6PLA2G7TRPV1CHRM2 | |
| SCHEMBL5335298 | 0.94 | MGLL (0.60) | MGLLABHD6PLA2G7TRPV1CHRM2 | |
| SCHEMBL15264216 | 0.89 | MGLL (0.55) | MGLLABHD6PLA2G7TRPV1CHRM2 | |
| SCHEMBL15264833 | 0.88 | MGLL (0.54) | MGLLABHD6PLA2G7TRPV1CHRM2 | |
| SCHEMBL5336442 | 0.87 | MGLL (0.53) | MGLLABHD6PLA2G7CHRM2CHRM4 | |
| SCHEMBL28630470 | 0.86 | PLA2G7 (0.53) | MGLLABHD6PLA2G7TRPV1CHRM2 | |
| SCHEMBL7986047 | 0.85 | CKS1B (0.57) | MGLLABHD6PLA2G7CHRM2CHRM4 | |
| SCHEMBL15265005 | 0.84 | MGLL (0.50) | MGLLABHD6PLA2G7TRPV1CHRM2 | |
| SCHEMBL16744505 | 0.84 | MGLL (0.54) | MGLLABHD6PLA2G7TRPV1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111454233-B | 4- (2- (pyrrolidine/piperidine-1-yl) benzyl) -piperazinylurea TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-111454233-A | 4- (2- (pyrrolidine/piperidine-1-yl) benzyl) -piperazinylurea TRPV1 antagonist and preparation and application thereof | 河南大学 | 2020-07-28 | — | — | CN | disclosed |