Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Anthrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.46 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 5/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anthrone SCHEMBL28448038 | 1.00 | MAOA (0.46) | MAOACES1BCHEALDH1A1CYP1A2 | |
| Anthrone SCHEMBL28021908 | 0.96 | MAOA (0.50) | MAOACES1BCHEALDH1A1CYP1A2 | |
| Anthraquinone SCHEMBL28146014 | 0.86 | MEN1 (0.41) | MAOACES1BCHEALDH1A1CYP1A2 | |
| Demannose SCHEMBL28270412 | 0.78 | TDP1 (0.33) | ALDH1A1KDM4EKMT2AMAPT | |
| Demannose SCHEMBL3028879 | 0.77 | LMNA (0.48) | CYP2C19KDM4E | |
| Demannose SCHEMBL14639546 | 0.77 | LMNA (0.48) | CYP2C19KDM4E | |
| Demannose SCHEMBL28812139 | 0.77 | LMNA (0.48) | CYP2C19KDM4E | |
| Demannose SCHEMBL31690723 | 0.77 | LMNA (0.48) | CYP2C19KDM4E | |
| Galactose SCHEMBL1176120 | 0.77 | LMNA (0.48) | CYP2C19KDM4E | |
| Demannose SCHEMBL1276048 | 0.77 | LMNA (0.48) | CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111206010-B | Recombinant bacillus amyloliquefaciens secreting extracellular alginate lyase and cellulase and application thereof | 杭州丰海生物科技有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-111206010-A | Recombinant bacillus amyloliquefaciens secreting extracellular alginate lyase and cellulase and application thereof | 杭州丰海生物科技有限公司 | 2020-05-29 | — | — | CN | disclosed |