Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.40 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.40 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.40 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28460213 | 0.92 | USP30 (0.45) | CNR1CNR2USP30BTKCHEK2 | |
| SCHEMBL28898963 | 0.91 | HDAC1 (0.46) | USP30BTKGPR119CHEK2HDAC4 | |
| SCHEMBL28461486 | 0.91 | GPR119 (0.46) | USP30GPR119CHEK2HDAC4HDAC6 | |
| SCHEMBL28458581 | 0.90 | SRC (0.47) | USP30BTKMEN1KMT2AGPR119 | |
| SCHEMBL28455501 | 0.88 | GPR119 (0.47) | USP30BTKMEN1KMT2AGPR119 | |
| SCHEMBL28458766 | 0.88 | BTK (0.42) | CNR1CNR2USP30BTKCHEK2 | |
| SCHEMBL28452589 | 0.86 | USP30 (0.45) | USP30BTKGPR119CHEK2HDAC4 | |
| SCHEMBL29968466 | 0.86 | GPR119 (0.48) | USP30BTKGPR119CHEK2HDAC4 | |
| SCHEMBL28458448 | 0.86 | GPR119 (0.48) | USP30BTKGPR119CHEK2HDAC4 | |
| SCHEMBL28456256 | 0.85 | FPR2 (0.48) | USP30MEN1KMT2ACHEK2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662232-B | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-08-02 | — | — | CN | disclosed |
| CN-111662232-A | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2020-09-15 | — | — | CN | disclosed |