Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 4/20 | 0.42 |
| ▸ | MMP9 | P14780 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28461597 | 0.92 | EGFR (0.50) | SRCALDH1A1HTTKDM4EHPGD | |
| SCHEMBL28898963 | 0.90 | HDAC1 (0.46) | BTKGPR119CHEK2USP30MMP13 | |
| SCHEMBL28461486 | 0.90 | GPR119 (0.46) | GPR119CHEK2USP30HDAC4HDAC6 | |
| SCHEMBL28449733 | 0.90 | CNR1 (0.46) | MEN1KMT2ABTKGPR119CHEK2 | |
| SCHEMBL28455501 | 0.88 | GPR119 (0.47) | ALDH1A1MEN1KMT2ABTKGPR119 | |
| SCHEMBL28898133 | 0.87 | APLNR (0.44) | SRCBTKCHEK2USP30ABL1 | |
| SCHEMBL28460213 | 0.86 | USP30 (0.45) | SRCBTKCHEK2USP30ABL1 | |
| SCHEMBL28452589 | 0.86 | USP30 (0.45) | SRCBTKGPR119CHEK2USP30 | |
| SCHEMBL29968466 | 0.85 | GPR119 (0.48) | BTKGPR119CHEK2USP30ABL1 | |
| SCHEMBL28456256 | 0.84 | FPR2 (0.48) | ALDH1A1MEN1KMT2ACHEK2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662232-B | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-08-02 | — | — | CN | disclosed |
| CN-111662232-A | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2020-09-15 | — | — | CN | disclosed |