Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29968466 | 1.00 | GPR119 (0.48) | GPR119KDM1AGBA1USP30FGFR3 | |
| SCHEMBL28461486 | 0.89 | GPR119 (0.46) | GPR119USP30FGFR3KDRCHEK2 | |
| SCHEMBL28452589 | 0.87 | USP30 (0.45) | GPR119USP30FGFR3KDRCHEK2 | |
| SCHEMBL28460213 | 0.87 | USP30 (0.45) | USP30FGFR3KDRCHEK2HPGDS | |
| SCHEMBL28461597 | 0.86 | EGFR (0.50) | USP30FGFR3KDRCHEK2IRAK1 | |
| SCHEMBL28898963 | 0.86 | HDAC1 (0.46) | GPR119USP30FGFR3KDRCHEK2 | |
| SCHEMBL28449733 | 0.86 | CNR1 (0.46) | GPR119USP30CHEK2BTKHDAC4 | |
| SCHEMBL28458581 | 0.85 | SRC (0.47) | GPR119USP30CHEK2ABL1BTK | |
| SCHEMBL28458345 | 0.85 | BTK (0.45) | GPR119USP30FGFR3KDRCHEK2 | |
| SCHEMBL28449732 | 0.83 | BTK (0.54) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662232-B | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-08-02 | — | — | CN | disclosed |
| CN-111662232-A | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2020-09-15 | — | — | CN | disclosed |