Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Dihydralazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.72 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | GOT1 | P17174 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydralazine SCHEMBL29950602 | 1.00 | ALDH1A1 (0.72) | ALDH1A1MAPTMAOAPTGS1TDP1 | |
| Dihydralazine SCHEMBL29794531 | 0.98 | ALDH1A1 (0.75) | ALDH1A1MAPTMAOAPTGS1TDP1 | |
| Dihydralazine SCHEMBL1374523 | 0.98 | ALDH1A1 (0.75) | ALDH1A1MAPTMAOAPTGS1TDP1 | |
| Dihydralazine SCHEMBL2129435 | 0.92 | ALDH1A1 (0.72) | ALDH1A1MAPTMAOAPTGS1TDP1 | |
| Dihydralazine SCHEMBL3462832 | 0.85 | ALDH1A1 (0.90) | ALDH1A1MAPTMAOAPTGS1TDP1 | |
| Dihydralazine SCHEMBL149629 | 0.85 | ALDH1A1 (1.00) | ALDH1A1MAPTMAOAPTGS1TDP1 | |
| Dihydralazine SCHEMBL29484435 | 0.85 | ALDH1A1 (1.00) | ALDH1A1MAPTMAOAPTGS1TDP1 | |
| Hydralazine SCHEMBL8703662 | 0.79 | ALDH1A1 (0.81) | ALDH1A1MAPTMAOAPTGS1TDP1 | |
| SCHEMBL19358618 | 0.78 | MAPT (0.75) | ALDH1A1MAPTMAOAPTGS1TDP1 | |
| SCHEMBL9748186 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTMAOAPTGS1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115108995-A | Preparation method of dihydralazine sulfate hydrate crystal form | 北京云鹏鹏程医药科技有限公司 | 2022-09-27 | — | — | CN | claimed |
| CN-115108995-A | Preparation method of dihydralazine sulfate hydrate crystal form | 北京云鹏鹏程医药科技有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-115108995-A | Preparation method of dihydralazine sulfate hydrate crystal form | 北京云鹏鹏程医药科技有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-115108995-A | Preparation method of dihydralazine sulfate hydrate crystal form | 北京云鹏鹏程医药科技有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-111610273-B | High performance liquid chromatography analysis method for dihydralazine sulfate related substances | 常州制药厂有限公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-111610273-A | High performance liquid chromatography analysis method for dihydralazine sulfate related substances | 常州制药厂有限公司 | 2020-09-01 | — | — | CN | disclosed |