Dihydralazine

Dihydralazine

SCHEMBL29484435

NNc1nnc(NN)c2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 1.00
MAPT P10636 4/20 1.00
TDP1 Q9NUW8 3/20 1.00
MAOA P21397 2/20 1.00
PTGS1 P23219 2/20 1.00
ADORA3 P0DMS8 1/20 1.00
OPRM1 P35372 1/20 1.00
KCNH2 Q12809 1/20 1.00
GOT1 P17174 3/20 0.75
KDM4E B2RXH2 6/20 0.59
CYP3A4 P08684 3/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
CYP1A2 P05177 3/20 0.59
TP53 P04637 2/20 0.59
LMNA P02545 2/20 0.59
CYP2D6 P10635 2/20 0.59
NPC1 O15118 1/20 0.59
MPO P05164 1/20 0.59
PKM P14618 1/20 0.59
THPO P40225 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dihydralazine SCHEMBL149629 1.00 ALDH1A1 (1.00) ALDH1A1MAPTTDP1MAOAPTGS1
Dihydralazine SCHEMBL3462832 0.95 ALDH1A1 (0.90) ALDH1A1MAPTTDP1MAOAPTGS1
SCHEMBL15721355 0.89 ALDH1A1 (0.78) ALDH1A1MAPTTDP1MAOAPTGS1
Dihydralazine SCHEMBL29794531 0.87 ALDH1A1 (0.75) ALDH1A1MAPTTDP1MAOAPTGS1
SCHEMBL19358618 0.87 MAPT (0.75) ALDH1A1MAPTTDP1MAOAPTGS1
SCHEMBL496520 0.87 GOT1 (1.00) ALDH1A1MAPTTDP1MAOAPTGS1
SCHEMBL31146711 0.87 GOT1 (1.00) ALDH1A1MAPTTDP1MAOAPTGS1
Dihydralazine SCHEMBL1374523 0.87 ALDH1A1 (0.75) ALDH1A1MAPTTDP1MAOAPTGS1
SCHEMBL7413898 0.87 ALDH1A1 (0.75) ALDH1A1MAPTTDP1MAOAPTGS1
Hydrochloric Acid SCHEMBL2646490 0.85 GOT1 (0.96) ALDH1A1MAPTTDP1MAOAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115925863-A Fugu obscurus antibacterial peptide ToNK-lysin and application thereof 河海大学 2023-04-07 CN claimed
CN-115925863-B Fugu obscurus antibacterial peptide ToNK-lysin and application thereof 河海大学 2025-09-30 CN disclosed
CN-115925863-B Fugu obscurus antibacterial peptide ToNK-lysin and application thereof 河海大学 2025-09-30 CN disclosed
US-20250041322-A1 HEAT STRESS RELIEVING AGENT NAGASE VIITA CO., LTD. (JP) 2025-02-06 US disclosed
WO-2023081825-A2 ACTIVE IMMUNIZATION AGAINST AMYLOID AND AGING-RELATED DISEASES UNIVERSITY OF KANSAS (US) 2023-05-11 WO disclosed
CN-115925863-A Fugu obscurus antibacterial peptide ToNK-lysin and application thereof 河海大学 2023-04-07 CN disclosed
CN-115925863-A Fugu obscurus antibacterial peptide ToNK-lysin and application thereof 河海大学 2023-04-07 CN disclosed
CN-115925863-A Fugu obscurus antibacterial peptide ToNK-lysin and application thereof 河海大学 2023-04-07 CN disclosed
US-20220062318-A1 HEAT STRESS RELIEVING AGENT Hayashibara Co., Ltd. (JP) 2022-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250041322-A1 HEAT STRESS RELIEVING AGENT HSF1, HEATR1, HSPA2 ALDH1A1 578/4885MAPT 2400/4885TDP1 1675/4885
US-20220062318-A1 HEAT STRESS RELIEVING AGENT HSF1, HEATR1, HSPA2 ALDH1A1 578/4885MAPT 2400/4885TDP1 1675/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.